Classifier Instance:

Anchor text: NPAS3
Target Entity: NPAS3
Preceding Context: Reelin pathway could also be linked to schizophrenia and other psychotic disorders through its interaction with risk genes. One example is the neuronal transcription factor
Succeeding Context: , disruption of which is linked to schizophrenia and learning disability. Knockout mice lacking NPAS3 or the similar protein NPAS1 have significantly lower levels of reelin; the precise mechanism behind this is unknown. Another example is the schizophrenia-linked gene MTHFR, with murine knockouts showing decreased levels of reelin in the cerebellum. Along the same line, it is worth noting that the gene coding for the subunit NR2B that is presumably affected by reelin in the process of NR2B->NR2A developmental change of NMDA receptor composition, stands as one of the strongest risk gene candidates. Another shared aspect between NR2B and RELN is that they both can be regulated by the TBR1 transcription factor.
Paragraph Title: null
Source Page: Reelin

Ground Truth Types:

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