Classifier Instance:

Anchor text: Edward B. Lewis
Target Entity: Edward_B\u002e_Lewis
Preceding Context: Evolutionary developmental biology (evo-devo) springs from clear proof that development is closely controlled by special genetic systems, and the hope that comparison of these systems will tell us much about the evolutionary history of different groups. In a series of experiments with the fruit-fly Drosophila,
Succeeding Context: was able to identify a complex of genes whose proteins bind to the cis-regulatory regions of target genes. The latter then activate or repress systems of cellular processes that accomplish the final development of the organism. Furthermore, the sequence of these control genes show co-linearity: the order of the loci in the chromosome parallels the order in which the loci are expressed along the anterior-posterior axis of the body. Not only that, but this cluster of master control genes programs the development of all higher organisms. Each of the genes contains a homeobox, a remarkably conserved DNA sequence. This suggests the complex itself arose by gene duplication. In his Nobel lecture, Lewis said "Ultimately, comparisons of the [control complexes] throughout the animal kingdom should provide a picture of how the organisms, as well as the [control genes] have evolved."
Paragraph Title: Evolutionary developmental biology
Source Page: Modern evolutionary synthesis

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