Classifier Instance:

Anchor text: J. B. S. Haldane
Target Entity: J\u002e_B\u002e_S\u002e_Haldane
Preceding Context: The geneticist
Succeeding Context: wondered why the dominant mutation that causes Huntington's disease remained in the population, and why natural selection had not eliminated it. The onset of this neurological disease is (on average) at age 45 and is invariably fatal within 10–20 years. Haldane assumed that, in human prehistory, few survived until age 45. Since few were alive at older ages and their contribution to the next generation was therefore small relative to the large cohorts of younger age groups, the force of selection against such late-acting deleterious mutations was correspondingly small. However, if a mutation affected younger individuals, selection against it would be strong. Therefore, late-acting deleterious mutations could accumulate in populations over evolutionary time through genetic drift. This principle has been demonstrated experimentally. And it is these later-acting deleterious mutations that are believed to allow—even cause—age-related mortality.
Paragraph Title: Evolutionary theories
Source Page: Senescence

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