Classifier Instance:

Anchor text: G protein-coupled receptor
Target Entity: G_protein\u002dcoupled_receptor
Preceding Context: When a ligand activates the
Succeeding Context: , it induces a conformational change in the receptor that allows the receptor to function as a guanine nucleotide exchange factor (GEF) that exchanges GDP for GTP on the G α subunit. In the traditional view of heterotrimeric protein activation, this exchange triggers the dissociation of the G α subunit, bound to GTP, from the G βγ dimer and the receptor. However, models that suggest molecular rearrangement, reorganization, and pre-complexing of effector molecules are beginning to be accepted. Both G α -GTP and G βγ can then activate different signaling cascades (or second messenger pathways) and effector proteins, while the receptor is able to activate the next G protein.
Paragraph Title: null
Source Page: G protein

Ground Truth Types:

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Predicted Types:

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wordnet_person_100007846-1.7121772044103594 0
yagoGeoEntity-2.188039210857432 0
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|  |---yagoGeoEntity