Classifier Instance:

Anchor text: Alick Isaacs
Target Entity: Alick_Isaacs
Preceding Context: Meanwhile, the British virologist
Succeeding Context: and the Swiss researcher Jean Lindenmann, at the National Institute for Medical Research in London, noticed an interference effect caused by heat-inactivated influenza virus on the growth of live influenza virus in chicken egg chorioallantoic membrane. They published their results, attaining wide recognition, in 1957; in this paper they coined the term "interferon", and today that specific interfering agent is known as a "Type I interferon". The majority of the credit for discovery of the interferon goes to Isaacs and Lindenmann, with whom there is no record of Nagano ever having made personal contact. The purification of interferons did not occur until 1978. A series of publications from the laboratories of Sidney Pestka and Alan Waldman between 1978 and 1981, describe the purification of the type I interferons IFN-α and IFN-β. By the early 1980s, the genes for these interferons were cloned allowing—for the first time—definitive proof that interferons really were responsible for interfering with viral replication. Gene cloning also confirmed that IFN-α was encoded by, not one gene, but a family of related genes. The type II IFN (IFN-γ) gene was also isolated around this time.
Paragraph Title: History
Source Page: Interferon

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