Classifier Instance:

Anchor text: NMDA receptor
Target Entity: NMDA_receptor
Preceding Context: Serotonin is a neurotransmitter involved in multiple states including aggression, pain, sleep, appetite, anxiety, depression, migraine, and vomiting. In humans the effects of excess serotonin were first noted in 1960 in patients receiving a monoamine oxidase inhibitor (MAOI) and tryptophan. The syndrome is caused by increased serotonin in the central nervous system. It was originally suspected that agonism of 5-HT 1A receptors in central grey nuclei and the medulla was responsible for the development of the syndrome. Further study has determined that overstimulation of primarily the 5-HT 2A receptors appears to contribute substantially to the condition. The 5-HT 1A receptor may still contribute through a pharmacodynamic interaction in which increased synaptic concentrations of a serotonin agonist saturate all receptor subtypes. Additionally, noradrenergic CNS hyperactivity may play a role as CNS norepinephrine concentrations are increased in serotonin syndrome and levels appear to correlate with the clinical outcome. Other neurotransmitters may also play a role
Succeeding Context: ;antagonists and GABA have been suggested as affecting the development of the syndrome. Serotonin toxicity is more pronounced following supra-therapeutic doses and overdoses, and they merge in a continuum with the toxic effects of overdose.
Paragraph Title: Pathophysiology
Source Page: Serotonin syndrome

Ground Truth Types:

Predicted Types:

Type	Confidence	Decision
wordnet_artifact_100021939	-2.6451064498930794	0
wordnet_event_100029378	1.0866815439022508	1
wordnet_act_100030358	0.6554340696702492	1
wordnet_action_100037396	-1.7825440718352163	0
wordnet_activity_100407535	-1.2233437287036366	0
wordnet_speech_act_107160883	-1.971451855115043	0
wordnet_group_action_101080366	-1.817418906871984	0
wordnet_communication_106252138	1.5074386587889004	1
wordnet_social_event_107288639	-2.49820389220227	0
wordnet_happening_107283608	-1.323911791633828	0
wordnet_group_action_101080366	-2.261517764539463	0
wordnet_organization_108008335	-1.2441246073825067	0
wordnet_person_100007846	-2.0528895476942646	0
yagoGeoEntity	-3.149108606763165	0