Classifier Instance:

Anchor text: Fran├žois Jacob
Target Entity: Fran\u00e7ois_Jacob
Preceding Context: Another central idea is that some gene products function as switches whereas others act as diffusible signals. Genes specify proteins, some of which act as structural components of cells and others as enzymes that regulate various biochemical pathways within an organism. Most biologists working within the modern synthesis assumed that an organism is a straightforward reflection of its component genes. The modification of existing, or evolution of new, biochemical pathways (and, ultimately, the evolution of new species of organisms) depended on specific genetic mutations. In 1961, however, Jacques Monod, Jean-Pierre Changeux and
Succeeding Context: discovered within the bacterium Escherichia coli a gene that functioned only when "switched on" by an environmental stimulus. Later, scientists discovered specific genes in animals, including a subgroup of the genes which contain the homeobox DNA motif, called Hox genes, that act as switches for other genes, and could be induced by other gene products, morphogens, that act analogously to the external stimuli in bacteria. These discoveries drew biologists' attention to the fact that genes can be selectively turned on and off, rather than being always active, and that highly disparate organisms (for example, fruit flies and human beings) may use the same genes for embryogenesis (e.g., the genes of the "developmental-genetic toolkit", see below), just regulating them differently.
Paragraph Title: null
Source Page: Evolutionary developmental biology

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