Classifier Instance:

Anchor text: Tau
Target Entity: Tau_protein
Preceding Context: Cyclin-dependent kinase 5 (Cdk5), a major regulator of neuronal migration and positioning, is known to phosphorylate DAB1 and other cytosolic targets of reelin signaling, such as
Succeeding Context: , which could be activated also via reelin-induced deactivation of GSK3B, and NUDEL, associated with Lis1, one of the DAB1 targets. LTP induction by reelin in hippocampal slices fails in p35 knockouts. P35 is a key Cdk5 activator, and double p35/Dab1, p35/RELN, p35/ApoER2, p35/VLDLR knockouts display increased neuronal migration deficits, indicating a synergistic action of reelin → ApoER2/VLDLR → DAB1 and p35/p39 → Cdk5 pathways in the normal corticogenesis.
Paragraph Title: Interaction with Cdk5
Source Page: Reelin

Ground Truth Types:

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